Nature communications
A proteogenomic atlas of 1032 brain metastases identifies molecular subtypes, immune landscapes, and therapeutic vulnerabilities.
Zhenyu Yang, Shiyou Wei, Hao Duan, Xiuqi Wang, Dainan Zhang, Karrie Mei-Yee Kiang, Yulan Deng, Yuanzhong Yang, Yin Ku, Wanming Hu, Chaowei Zou, Meiqin Tang, Yu Jiang, Yu Liu, Hongbin Lan
Published: 202610.1038/s41467-026-68748-y
Abstract
The molecular heterogeneity of brain metastases hampers therapeutic development for cures. To address this unmet and urgent need, we construct a comprehensive multi-omic, single cell, and spatially resolved atlas of 1,032 pan-cancer brain metastases,…
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