Nature communications
Kynurenine mediates the chemotherapy-induced intestinal toxicity through modulation of gut microbiota.
Hongyu Xie, Jingyi Yang, Jinjie Wu, Wenhao Ma, Haoyang Xu, Shuang Guo, Yanchun Xie, Zhanhao Luo, Dayi Liang, Mujia Cao, Danling Liu, Sanqing Jin, Ping Lan, Zhen He
Published: 202610.1038/s41467-026-68741-5
Abstract
Chemotherapy-induced intestinal toxicity is a major dose-limiting complication, but the underlying mechanisms linking systemic metabolism to localized gut damage are poorly understood. Here we show that serum L-kynurenine, a tryptophan metabolite, is…
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