Nature communications
Improving polygenic score prediction for underrepresented groups through transfer learning.
Hao Wu, Paulino Pérez-Rodríguez, Michael Boehnke, Yuehua Cui, Xiaoyu Liang, Ana I Vazquez, Gustavo de Los Campos
Published: 202610.1038/s41467-026-68696-7
Abstract
The advent of large biobanks has substantially increased the accuracy of polygenic scores (PGS). However, most existing PGSs were derived from European-ancestry data and often exhibit reduced predictive performance when applied to individuals of non-…
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