Nature communications
Molecular recognition of thyroglobulin by sortilin.
Irene Boniardi, Giorgia Tanzi, Alessio Di Ianni, Andrea Graziadei, Marko Nedeljković, Camilla Stejskalova, Francesca Coscia
Published: 202610.1038/s41467-026-68658-z
Abstract
Sortilin is a ubiquitous membrane receptor mediating trafficking of protein cargoes. In the thyroid, sortilin binds thyroglobulin (TG) during its endocytosis, a key process in thyroid homeostasis. Although sortilin has been proposed to recognise high…
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