Nature communications
WDR5 remodels NANOG condensates to drive transcriptional programs and sustain stem cell identity.
Duo Wang, Xianle Shi, Jiaying Xie, Lijie Zhao, Bin Wu, Qiman Dong, Yaoguang Huang, Jinlong Suo, Xinyu Wang, Beixuan He, Shukun Yan, Hongjuan Xue, Yuheng Shi, Yingbin Liu, Jianlong Wang
Published: 202610.1038/s41467-026-68623-w
Abstract
Stem cell pluripotency relies on a finely tuned interplay between transcription factors and epigenetic regulators. Here, we identify a direct interaction between NANOG, a master pluripotency transcription factor, and WDR5, a core chromatin regulator…
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