Nature communications
Dynamic signature of activity-stability tradeoff in lactamase evolution.
Ernesto Arcia, Dimitra Keramisanou, Lian M C Jacobs, McKenna Parker, Julián M Delgado, Vasantha Kumar Mv, Sameer Varma, Rinat Abzalimov, Yu Chen, Ioannis Gelis
Published: 202610.1038/s41467-026-68620-z
Abstract
Our ability to understand protein evolution hinges on understanding how evolutionary landscapes are shaped at the fundamental protein level. Using TEM-1 β-lactamase we show that molecular traits related to the statistical ensemble nature of protein s…
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