Nature communications
Spatiotemporally controlled drug release via a click-release system utilizing mono-alkyl-hydroxylamine and cyclooctyne chemistry.
Xiaowei Xu, Xidan Tong, Yangfei Shi, Xin Wang, Yanzhao Chen, Yuanan Wang, Mingxin Cheng, Shuanglong Chen, Hao Hao, Yan Liang, Weiwei Guo, Yueqin Zheng
Published: 202610.1038/s41467-026-68502-4
Abstract
The advancement of bioorthogonal bond-breaking chemistry requires precise spatiotemporal control over chemical reactions. In this study, we introduce a click-release strategy based on the reaction between mono-alkyl-hydroxylamine and cyclooctyne (COT…
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