Nature communications
Serine inhibits granulosa cell ferroptosis to maintain ovarian function.
Hao-Cheng Gu, You-Qiong Zhuo, Ling-Fang Wang, Yu-Wei Zhang, Dong-Shui Li, Ling-Qin Chen, Zhi-Hua Li, Yun-Yue Wang, Yi-Kai Wang, Hui-Ting Liao, Jia-Qin Wu, Shi-Qing Tao, Xing-Yu Wei, Ke-Yu Deng, Hong-Bo Xin
Published: 202610.1038/s41467-026-68440-1
Abstract
Cyclophosphamide (CTX) is a primary medicine for curing breast cancer which often causes premature ovarian insufficiency (POI). Our recent publication reveals that CTX induces POI by promoting the expression of SLC1A4, a transporter of serine efflux,…
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