Nature communications
Phosphorothioate DNA modification by BREX type 4 systems in the human gut microbiome.
Yifeng Yuan, Michael S DeMott, Shane R Byrne, Katia Flores, Mathilde Poyet, Mathieu Groussin, Brittany Berdy, John Rusine Bahunde, Catherine Girard, Jenni Lehtimäki, Audax Z P Mabulla, Ivan Emil Mwikarago, Yvonne Ayerki Nartey, Le Thanh Tu Nguyen, Charles A Onyekwere
Published: 202610.1038/s41467-026-68412-5
Abstract
Among dozens of microbial DNA modifications regulating gene expression and host defense, phosphorothioation (PT) is the only known backbone modification, with sulfur inserted at a non-bridging oxygen by dnd and ssp gene families. Here we explored the…
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