Nature communications
OCT4 enhances the firing efficiency of late DNA replication origins in mouse embryonic stem cells.
Eddie Rodriguez-Carballo, Vasilis S Dionellis, Sotirios G Ntallis, Lilia Bernasconi, Ezgi G Keskin, Thanos D Halazonetis
Published: 202610.1038/s41467-026-68389-1
Abstract
DNA replication initiates at specific genomic regions known as initiation zones (IZs), which follow a defined spatiotemporal program that is partially dependent on cell type. Here, we examine the replication-initiation patterns of pluripotent mouse e…
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