Nature communications
OTX2 inhibits human pluripotent stem cell reprogramming toward 8-cell-like and morula-like states.
Xi Kong, Nan Jiang, Shaowei Chen, Xingyou Zhang, An Huang, Li Hu, Simeng Yi, Shigang Yin, Jianhua Peng, Yong Jiang, Huangfan Xie, Bingqing Xie
Published: 202610.1038/s41467-026-68388-2
Abstract
In human embryos, major zygotic genome activation (ZGA) initiates at the 8-cell (8C) blastomere stage, marking the start of the ontogenesis program. Recent advancements have shown that primed human pluripotent stem cells (hPSCs) can be reprogrammed t…
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