Nature communications
Sequence-based generative AI design of versatile tryptophan synthases.
Théophile Lambert, Amin Tavakoli, Gautham Dharuman, Jason Yang, Vignesh Bhethanabotla, Sukhvinder Kaur, Matthew Hill, Arvind Ramanathan, Anima Anandkumar, Frances H Arnold
Published: 202610.1038/s41467-026-68384-6
Abstract
Enzymes are powerful and sustainable catalysts, but their widespread application is limited by the difficulty of identifying functional starting points for optimization, creating a major bottleneck in early- stage biocatalyst discovery. Designing lib…
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