Nature communications
Engineered VPg saRNA achieves cap-independent, low-immunogenic and precise encoding of therapeutic proteins in vivo.
Zunyong Feng, Liuxi Chu, Qiang Li, Jing Zhou, Ping Wu, Xuanbo Zhang, Yuanbo Pan, Jianhua Zou, Qun Chen, Zhiliang Xu, Liang Yan, Yanjiao Huang, Xiaokun Li, Zhouguang Wang, Xiaoyuan Chen
Published: 202610.1038/s41467-026-68364-w
Abstract
Self-amplifying mRNA (saRNA) vectors hold promise for the sustained expression of mRNA vaccines in vivo. However, their inherently high immunogenicity and low-fidelity replication-stemming from the RNA viral genome's replication mechanisms-limit thei…
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