Nature communications
Structure of SHOC2-KRAS-PP1C complex reveals RAS isoform-specific determinants and insights into targeting complex assembly by RAS inhibitors.
Daniel A Bonsor, Lorenzo I Finci, Jacob R Potter, Lucy C Young, Vanessa E Wall, Ruby Goldstein de Salazar, Katie R Geis, Tyler Stephens, Joseph Finney, Dwight V Nissley, Frank McCormick, Dhirendra K Simanshu
Published: 202610.1038/s41467-026-68319-1
Abstract
RAF activation is essential for MAPK signaling and is mediated by RAS binding and the dephosphorylation of a conserved phosphoserine by the SHOC2-RAS-PP1C complex. MRAS forms a high-affinity SHOC2-MRAS-PP1C (SMP) complex, while canonical RAS isoforms…
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