Nature communications
HEXIM1 inter-monomer autoinhibition governs 7SK RNA binding specificity and P-TEFb inactivation.
Yuan Yang, Maria Grazia Murrali, Sabrina Galvan, Yaqiang Wang, Christine Stephen, Neha Ajjampore, Xiaoyu Wang, Juli Feigon
Published: 202610.1038/s41467-026-68285-8
Abstract
Hexim proteins are key RNA-dependent regulators of eukaryotic transcription through 7SK-dependent sequestration and inactivation of the kinase P-TEFb (Cdk9-CyclinT1/2) in the 7SK RNP. P-TEFb activity drives release of RNA polymerase II from promoter-…
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