Nature communications
DNA actively regulates the "safety-belt" dynamics of condensin during loop extrusion.
Jinyu Chen, Cibo Feng, Yong Wang, Xiakun Chu
Published: 202610.1038/s41467-025-68239-6
Abstract
Condensin plays an essential role in genome folding through its active DNA loop extrusion activity. Condensin contains a binding interface between its Ycg1 HEAT-repeat subunit and the Brn1 kleisin, together forming a "safety-belt" DNA-binding groove.…
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