Nature communications
Volumetric compression regulates the phase separation of AXIN and acts as an operational amplifier to bidirectionally modulate Wnt signaling in organoids.
Jinyun Shi, Linze Wu, Pengjie Li, Fukang Qi, Mengcheng Lei, Xueqing Ren, Han Xie, Wenhui Wang, Yi Zheng, Peng Chen, Limin Xia, Chen Shi, Yu Zhang, Bi-Feng Liu, Yiwei Li
Published: 202610.1038/s41467-025-68209-y
Abstract
Protein phase separation has emerged as a crucial mechanism for spatiotemporal regulation of intracellular processes, yet its potential to integrate and compute diverse extracellular signals is not fully understood. Here, we show a mechano-biochemica…
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