Nature communications
A programmable ribozyme for RNA signal transduction.
Mandy Yu Theng Lim, Chermaine Tan, Charannya Sozheesvari Subhramanyam, Shi Jie Teo, Louis DeFalco, Samuel Kevin Pasaribu, Chong Hui Koh, Dheeraj Rayamajhi, Jieying Chi, Shengnan Li, Keng Boon Wee, Sudipto Roy, Roland G Huber, Sherry Shiying Aw
Published: 202610.1038/s41467-025-68175-5
Abstract
RNA detection applications can be augmented if a sensed RNA can be directly functionally transduced. However, there is no generalisable approach that allows an RNA trigger itself to directly activate diverse non-coding RNA effectors. Here, we report…
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