Nature communications
Time-resolved multiomics profiling reveals chromatin O-GlcNAc modification promotes senescence-associated transcriptional program.
Nana Zhang, Ran Zhao, Xiaomin Zhong, Qian Dong, Yajie Liu, Kairan Yu, Lirui Han, Fanxu Meng, Jiaxuan Wu, Qiushi Chen, Xuechen Li, Qingbin Chen, Keren Zhang, Huang Huang, Jianing Zhang
Published: 202610.1038/s41467-025-68143-z
Abstract
O-GlcNAc modification is a key cellular signal, but its role in regulating senescence-associated transcription remains poorly understood. Here, we apply a time-resolved chemical genomics strategy to map dynamic O-GlcNAc chromatin-associated proteins…
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