Nature communications
Preventing premature deaths through polygenic risk scores.
Melisa Chuong, Deborah Thompson, Michael E Weale, Fernando Riveros-Mckay, Nilesh J Samani, Daniel Wells, Vincent Plagnol, Gil McVean, Euan A Ashley, Peter Donnelly, Seamus Harrison, Jack W O'Sullivan
Published: 202610.1038/s41467-025-68129-x
Abstract
Polygenic risk scores (PRS) have demonstrated predictive validity across a range of cohorts and diseases, but quantifying their clinical utility remains a challenge. As PRS can be derived from a single biological sample and remains stable throughout…
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