Nature communications
Phosphoproteomics of aged insulin-resistant bone identifies P70S6K phosphorylation of AFF4 as a gene-specific transcriptional regulator.
Mriga Dutt, Luoping Liao, Hani Jieun Kim, Ronnie Blazev, Audrey Chan, Hitesh Kore, Ayenachew Bezawork-Geleta, Li Dong, Isela Sarahi Rivera, Natalie K Y Wee, Jeffrey Molendijk, Julian P H Wong, Vanessa R Haynes, Veronica Uribe, Gordon S Lynch
Published: 202510.1038/s41467-025-68106-4
Abstract
Insulin action on the skeleton is essential for bone development and whole-body energy metabolism, however a global view of signaling in this tissue is lacking. Furthermore, whether there are signaling differences that drive the gene-specific activat…
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