Nature communications
Airway immune profiles and therapeutic implications of IGF1 in eosinophilic granulomatosis with polyangiitis.
Cong Dong, Bingtai Lu, Changhao Zhong, Changxing Ou, Xiaojing Yang, Lingwei Wang, Xiaoyu Zuo, Lingna Xue, Chenyang Lu, Shang Wang, Junjie Wen, Jianjuan Ma, Zhenan Deng, Yiyi Liu, Liuheyi Ma
Published: 202610.1038/s41467-025-68104-6
Abstract
Eosinophilic granulomatosis with polyangiitis (EGPA) and severe eosinophilic asthma (SEA) share a Type 2 (T2) inflammatory signature but exhibit distinct pathophysiology. We hypothesized that EGPA involves additional inflammatory mechanisms, beyond T…
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