Nature communications
Molecular mechanism of exchange coupling in CLC chloride/proton antiporters.
Deniz Aydin, Chih-Ta Chien, Jürgen Kreiter, Amy R Nava, Jasmina M Portasikova, Lukas Fojtik, Briana L Sobecks, Catalina Mosquera, Petr Man, Ron O Dror, Wah Chiu, Merritt Maduke
Published: 202610.1038/s41467-025-68098-1
Abstract
The ubiquitous CLC membrane transporters are unique in their ability to exchange anions for cations. Despite extensive study, there is no mechanistic model that fully explains their 2:1 Cl‒/H+ stoichiometric exchange mechanism. Here, we provide such…
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