Nature communications
METTL3 abrogation promotes glioma progression through regulating the ISG15-FASN axis-mediated lipid metabolism in macrophages.
Huilong Yin, Xiaoyi Yu, Chenglong Hu, Yuhang Yang, Mengke Wang, Yating Xing, Baile Zuo, Chenxing Zhang, Weilong Yang, Yitong Li, Zhuoya Yin, Lijun Zhao, Haijun Ma, Yu Chen, Chaowei Wang
Published: 202610.1038/s41467-025-68079-4
Abstract
Tumor-associated macrophages (TAMs) constitute a pivotal cellular component within the intricate tumor microenvironment (TME). However, the relationship between the N6-methyladenosine (m6A) and metabolic pattern of TAMs remains poorly understood. Her…
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