Nature communications
Butyrophilin 2A2 promotes T cell immunoregulation via CD45 phosphatase activation and protects against murine autoimmune glomerulonephritis and pregnancy loss.
Shafat Ali, Anders H Berg, Michifumi Yamashita, Ambart E Covarrubias, Jordan Mundell, Pranali N Shah, Ruan Zhang, Vincent Dupont, Bong-Ha Shin, Shen Yang, Madhusudhanarao Katiki, Ramachandran Murali, Margareta D Pisarska, Ravi Thadhani, Peter S Heeger
Published: 202610.1038/s41467-025-68077-6
Abstract
B7 costimulatory family member Butyrophilin 2A2 (BTN2A2) is predominantly expressed by antigen presenting cells and regulates T cell immunity, but molecular mechanisms are unclear. Using immunoblots analyzing TCR-initiated signaling intermediaries, c…
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