Nature communications
A nose-to-brain axis for spoiled food odor-triggered defensive responses in male mice.
Wan-Ying Dong, Ping-Kai Cheng, Jun-Hao Miao, Pei Shi, Ji-Ye Huang, Yu-Xin Jin, Qian-Qian Lou, Haitao Wang, Zerui Wang, Wan Zhao, Zhi Zhang, Wei Wang, Qi-Xin Zhou, Xia Zhu
Published: 202610.1038/s41467-025-68057-w
Abstract
Rancid odors can trigger retching and aversion in humans that prevent consumption of spoiled food, and consequently metabolic dysregulation, but the underlying neural mechanisms remain unclear. Here, we show that exposure to 2-methylbutyric acid (2MB…
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