Nature communications
Dual-action bisphosphonate hydrogel preserves cortical bone integrity and restores healing cascade in osteoporotic fracture-related infection.
Jie Li, Yang Zhang, Yi Liu, Yanjie Xu, Hui Xu, Qiangjun Ling, Zhen Tian, Chen Ling, Ziyang Tang, Kiram Abdukahar, Yang Li, Zongshan Hu, Yong Qiu, Liming Bian, Zezhang Zhu
Published: 202610.1038/s41467-025-68036-1
Abstract
In osteoporotic fracture-related infection (FRI), the coordinated bone healing is compromised by cortical bone lysis and persistent bacterial colonization. Current treatments primarily focus on infection control, but fail to preserve bone microarchit…
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