Nature communications
Functional implications of polygenic risk for schizophrenia in human neurons.
P J Michael Deans, Kayla G Retallick-Townsley, Aiqun Li, Carina Seah, Jessica Johnson, Judit Garcia Gonzalez, Evan Cao, Nadine Schrode, Alex Yu, Sam Cartwright, Georgios Voloudakis, Wen Zhang, Minghui Wang, John F Fullard, Kiran Girdhar
Published: 202610.1038/s41467-025-67959-z
Abstract
Genome wide association studies of schizophrenia reveal a complex polygenic risk architecture comprised of hundreds of risk variants; most are common in the population, non-coding, and act by genetically regulating the expression of one or more gene…
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