Nature communications
Dynamic neutrophil-keratinocyte communication network centered on IL-36/TNFSF15 responses characterizes inflammatory responses in generalized pustular psoriasis.
Rundong Jiang, Joseph Kirma, Jennifer Fox, Xianying Xing, Jiaqi Wang, Mrinal K Sarkar, Rachael Bogle, Tran Do, Anthony Coon, Christopher Cole, Olesya Plazyo, Joanna E Rew, Haihan Zhang, J Michelle Kahlenberg, Allison C Billi
Published: 202510.1038/s41467-025-67917-9
Abstract
Generalized pustular psoriasis (GPP) is a severe subtype of psoriasis characterized by epidermal neutrophil infiltration, often presenting as acute, potentially life-threatening flares. However, the characterization of the immune micro-environment in…
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