Nature communicationsFemaleOvarian NeoplasmsAnimalsTumor MicroenvironmentMacrophages
Hypoxia-driven remodeling of SELENOP+ macrophages shapes T cell dynamics and promotes ovarian cancer metastasis.
Qing Liu, Chenzhao Feng, Tianhao Wu, Siyang Zhang, Xinyi Wang, Qian Zhao, Xueying Song, Shuangyan Liu, Linru Quan, Yuli Zhang, Shimin Zhang, Bin Yang, Jixin Li, Gang Chen, Xuanzhang Huang
Published: 202610.1038/s41467-025-67859-2
Abstract
High-grade serous ovarian cancer (HGSOC) is characterized by extensive transcoelomic dissemination and the accumulation of ascites. However, how site-specific tumor microenvironment (TME) drives progression remains unknown. Here we show the co-occurr…
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