Nature communicationsAnimalsFemalePregnancyCardiomyopathiesHeart Failure
Peptidyl-tRNA hydrolase 2 is a negative regulator of peripartum cardiomyopathy with heart failure in female mice.
Vanessa Montoya-Uribe, Pooja Choubey, Chad B Walton, Natalija Glibetic, Won Seok Yang, Femke J Aan, Sarah Lindsey, Karolina Peplowska, Brenda Y Hernandez, Joe W Ramos, Michelle L Matter
Published: 202510.1038/s41467-025-67852-9
Abstract
The peptidyl-tRNA hydrolase 2 (PTRH2, Bit-1, BIT1) gene plays a pro-survival role during development with loss of function gene mutations causing congenital infantile multisystem disease (IMNEPD). In wild-type female mice hearts, Ptrh2 protein levels…
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