Nature communicationsCryoelectron MicroscopyMolecular Dynamics SimulationTRPV Cation ChannelsLigandsBayes Theorem
Comparing cryo-EM methods and molecular dynamics simulation to investigate heterogeneity in ligand-bound TRPV1.
Miro A Astore, David Silva-Sánchez, Robert Blackwell, Pilar Cossio, Sonya M Hanson
Published: 202510.1038/s41467-025-67821-2
Abstract
Cryogenic electron microscopy (cryo-EM) has emerged as a powerful method for resolving the structure of biological macromolecules. Recently, several computational methods have been developed to study the heterogeneity of molecules in single-particle…
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