Nature communicationsActomyosinAnimalsEndothelial CellsKRIT1 ProteinHumans
Circumferential actomyosin bundles anchored by CCM1 drive endothelial cell contraction and vessel constriction.
Yan Chen, Nuria Taberner, Jason da Silva, Vivek Semwal, Biplab Bhattacherjee, Julia Eckert, Igor Kondrychyn, Mingzhao Hu, Nitish Aswani, Guihua Chen, Yasushi Okada, Anne Karine Lagendijk, Tatsuo Shibata, Satoru Okuda, Li-Kun Phng
Published: 202510.1038/s41467-025-67820-3
Abstract
Blood vessels undergo extensive remodelling to acquire appropriate diameters, yet how endothelial cells coordinate changes in their number and shape to achieve this remains unclear. Here we show that endothelial cell contraction and rearrangements un…
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