Nature communicationsBilirubinHemeCarbon MonoxideOxidation-ReductionIron
Systemic engineering and global regulation enabling high-level bilirubin biosynthesis.
Zhentao Jiang, Jingxin Rao, Caokai Zhu, Yamiao Li, Qiang Zhu, Mingyue Zheng, Wenchi Zhang, Rongzhen Zhang
Published: 202510.1038/s41467-025-67804-3
Abstract
Bilirubin biosynthesis has long been constrained by low yields and poorly understood bottlenecks. Here, we report a fully in vitro pathway that converts heme to bilirubin with the titer of 1.7 g/L and 95.8%. Systematically, enzyme screening and mecha…
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