Nature communicationsHumansAneuploidyKaryotypeGenetic FitnessDNA Copy Number Variations
ALFA-K: Local adaptive mapping of karyotype fitness landscapes.
Richard J Beck, Tao Li, Noemi Andor
Published: 202510.1038/s41467-025-67750-0
Abstract
Despite its critical role in tumor evolution, a detailed quantitative understanding of the evolutionary dynamics of aneuploidy remains elusive. Here we introduce ALFA-K (Adaptive Local Fitness landscapes for Aneuploid Karyotypes), a method that infer…
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