Nature communicationsSupranuclear PalsyProgressivetau ProteinsHumansAged
4R-tau seeding activity reveals molecular subtypes in progressive supranuclear palsy.
Ivan Martinez-Valbuena, Seojin Lee, Enrique Santamaria, Joaquín Fernández-Irigoyen, Shelley L Forrest, Silvia Zampar, Jun Li, Hidetomo Tanaka, Blas Couto, Nikolai Gil D Reyes, Syeda Hania Qamar, Ali M Karakani, Ain Kim, Konstantin Senkevich, Ekaterina Rogaeva
Published: 202510.1038/s41467-025-67744-y
Abstract
Progressive supranuclear palsy (PSP) is a neurodegenerative disease characterized by abnormal accumulation of the protein tau in the brain, leading to motor and cognitive symptoms that vary between individuals. The reasons for this clinical heterogen…
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