Nature communicationsCOP9 Signalosome ComplexCryoelectron MicroscopyHumansUbiquitinationCullin Proteins
Structural basis of CSN-mediated SCF deneddylation.
Shan Ding, Julie A Clapperton, Märt-Erik Mäeots, Simone Kunzelmann, Mohammed Shaaban, Radoslav I Enchev
Published: 202610.1038/s41467-025-67566-y
Abstract
Cullin-RING ligases (CRLs) are the largest family of E3 ligases, with ubiquitination activity dynamically regulated by neddylation and deneddylation by the COP9 signalosome (CSN). CSN-mediated deneddylation not only deactivates CRLs but also enables…
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