Nature communications
Reduction of RAD23A extends lifespan and mitigates pathology in a mouse model of TDP-43 proteinopathy.
Xueshui Guo, Ravindra Singh Prajapati, Jiyeon Chun, Insuk Byun, Kamil K Gebis, Yi-Zhi Wang, Karen Ling, Casey Dalton, Jeff A Blair, Anahid Hamidianjahromi, Gemma Bachmann, Frank Rigo, Paymaan Jafar-Nejad, Jeffrey N Savas, Min Jae Lee
Published: 202610.1038/s41467-025-65104-4
Abstract
Protein misfolding and aggregation are cardinal features of neurodegenerative disease (NDD) and they contribute to pathophysiology by both loss-of-function (LOF) and gain-of-function (GOF) mechanisms. This is well exemplified by TDP-43 which aggregat…
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