Genes and immunity
YTHDF1 mediates KLF2/VSIG4 axis to regulate Kupffer cell polarization to alleviate sepsis-induced liver injury.
Na Sun, Yunhai Wu, Bin Liu, Peihua Xu, Guoqiang Shen, Jinlong Li, Chonghao Ma, Zongxuan Zhang
Published: 202510.1038/s41435-025-00367-x
Abstract
The severity and prognosis of sepsis patients are directly linked to liver damage. Encouraging Kupffer cell transition from M1 to M2 can notably diminish inflammation and hepatic damage triggered by sepsis. Here, the effect of YTH domain N6-methylade…
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