Gene therapy
CRISPR-AuNP: physicochemical optimization of a gold nanoparticle platform for cost-effective and modular non-viral gene editing in HSPCs.
Karthikeya S V Gottimukkala, Daniel D Lane, Rachel Cunningham, Haleema S Malik, Youngseo Jwa, Molly E Cassidy, Jack M P Castelli, Mark R Enstrom, Katrina Poljakov, Grady Gastelum, Samuel H Ho, Carlos Tassa, Jennifer E Adair
Published: 202610.1038/s41434-025-00591-0
Abstract
Efficient delivery of CRISPR ribonucleoproteins into primary hematopoietic stem and progenitor cells (HSPCs) is essential for durable gene editing therapies but remains challenging. Here, we advance a modular, benchtop-assembled gold-polymer hybrid n…
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