Gene therapy
Antibody-guided AAV vectors for antigen-specific delivery of suicide genes.
Shojiro Inano, Hiroyuki Morita, Daishi Nakagawa, Akifumi Takaori-Kondo, Takako Nakajima
Published: 202510.1038/s41434-025-00570-5
Abstract
Antibody-drug conjugates (ADCs) are a promising class of targeted cancer therapeutics, but their efficacy is often limited by off-target toxicity caused by payload leakage after internalization into tumor cells. To overcome this, we developed an ADC…
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