Cell research
Zinc accumulation-induced integrated stress response triggers β-cell identity loss.
Qing Ma, Wenjun Xu, Xuan Wang, Haoyu Nie, Yukun Gao, Rui Hu, Zhihao Yang, Xushu Wang, Ta Na, Xiangyi Chen, Zhaoyue Wang, Minglu Xu, Li Shao, Meng Guo, Yanfang Liu
Published: 202610.1038/s41422-026-01222-y
Abstract
Pancreatic β-cell identity loss is increasingly recognized as a critical pathogenic contributor to β-cell failure in type 2 diabetes (T2D), but the specific mechanism remains to be characterized. In this study, we demonstrate that zinc accumulation c…
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