Cell death discovery
IL‑1 receptor antagonism attenuates renal fibrosis via RNF182‑driven MFN2 destabilization and mitochondrial dysfunction.
Bo Yang, Qing Shao, Wei Wang, Maoting Li, Fanzhou Zeng, Xuezi Fu, Jun Liu, Cheng Xue, Nanmei Liu
Published: 202510.1038/s41420-025-02929-4
Abstract
Renal fibrosis is a major driver of chronic kidney disease (CKD) progression, yet targeted therapies remain limited due to incomplete understanding of key molecular mechanisms. While IL-1-mediated inflammation and mitochondrial dysfunction are recogn…
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