Cell death discovery
UCHL1 stabilizes Twist1 via K11/K63-linked deubiquitination to drive tumor metastasis in non-small cell lung cancer.
Qin Feng, Qianfang Hu, Qinghe Huang, Jingxing Yang, Ying Zhu, Feng Wang, Jianyu Xu, Sha Hu, Rujuan Zheng, Hui Shi, Zengyan Zhu, Xinyuan Ding, Wenjuan Wang
Published: 202510.1038/s41420-025-02925-8
Abstract
Deubiquitinating enzymes (DUBs) are critical regulators of protein turnover and have emerged as key players in cancer progression. In this study, we demonstrated that ubiquitin C-terminal hydrolase L1 (UCHL1) is upregulated in non-small cell lung can…
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