Cell death discovery
The glycolytic enzyme PFKFB3 alleviates DNA damage and chondrocyte senescence in osteoarthritis.
Bo Liu, Chenzhong Wang, Ziyu Weng, Yi Yang, Yi Shi, Chi Zhang
Published: 202510.1038/s41420-025-02903-0
Abstract
Chondrocyte senescence is a key driver of osteoarthritis (OA) progression. This study examined the role of the glycolytic enzyme PFKFB3 in regulating chondrocyte senescence during OA. Using a destabilization of the medial meniscus (DMM) mouse model,…
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