Cell death discovery
Glutamine: fructose-6-phosphate amidotransferase (GFAT) in the pathology of diseases: a review.
Caiting Yang, Fengyu Chu, Xiaoli Chen, Fanqi Meng, Yinhao Li, Jingwen Chen, Chaoyang Sun, Yahui Shang, Ruibin Guo, Jianming Wang, Changxin Wu, Huiping Duan, Miaomiao Shao, Wei Yuan
Published: 202510.1038/s41420-025-02898-8
Abstract
Glutamine: fructose-6-phosphate amidotransferase (GFAT), a conserved enzyme across prokaryotic and eukaryotic species, is the first and rate-limiting step in the hexosamine biosynthetic pathway (HBP), diverting 2-5% of fructose-6-phosphate derived fr…
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