Cell death discovery
IL-1β+ lung-resident macrophages mediate endothelial dysfunction and acute lung injury in sepsis through immune-metabolic crosstalk.
Yang Dong, Tianyuan Li, Bei Fang, Dingde Long, Ying Tian, Huan Fu
Published: 202510.1038/s41420-025-02868-0
Abstract
Sepsis-induced acute lung injury (ALI) involves a complex interplay between immune cells and the pulmonary endothelium. However, the molecular regulators that coordinate this interaction remain poorly defined. In a murine sepsis model, we identified…
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