Cell death & diseaseHumansHodgkin DiseaseTumor MicroenvironmentTumor-Associated MacrophagesProto-Oncogene Proteins c-pim-1
PIM kinase inhibition attenuates pro-tumoral and immunosuppressive functions of macrophages in classic Hodgkin lymphoma.
Maciej Szydłowski, Ewa Kurtz, Filip Garbicz, Julia Maroszek, Michał Pawlak, Natalia Ochocka, Marcin Tabaka, Monika Prochorec-Sobieszek, Anna Szumera-Ciećkiewicz, Patryk Górniak, Olga Szymańska-Giemza, Grzegorz Rymkiewicz, Agnieszka Kołkowska-Leśniak, Wojciech Kukwa, Ewa Paszkiewicz-Kozik
Published: 202510.1038/s41419-025-08402-5
Abstract
Tumor-associated macrophages (TAMs) of classic Hodgkin Lymphoma (cHL) contribute to the development of immunosuppressive tumor microenvironment (TME) and are associated with worse treatment outcomes. However, detailed features, functions and therapeu…
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