Cell death & disease
The investigational anti-B7-H3 antibody-drug conjugate vobramitamab duocarmazine exerts anti-tumor activity in vitro and in vivo in pediatric sarcoma preclinical models.
Giovanna Bianchi, Fabio Pastorino, Gaia Rolandi, Eleonora Ciampi, Daniela Segalerba, Barbara De Giovanni, Barbara Cafferata, Matilde Balbi, Silvia Ravera, Valerio Gaetano Vellone, Mirco Ponzoni, Chiara Brignole
Published: 202610.1038/s41419-025-08397-z
Abstract
Prognosis for pediatric sarcoma (pSC)-affected patients, especially those with relapsed/refractory disease, is dismal. The available treatment options are unsatisfactory, challenging researchers to address this unmet need. The investigational B7-H3 t…
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