Cell death & disease
CYP8B1 inhibits hepatocellular carcinoma progression by repressing PAK4 transcription through inhibition of nuclear translocation of u-STAT1.
Le Xu, Lin Xiong, Jingping Yuan, Yukai Chen, Fangfang Chen, Siyu Wang, Ximing Xu
Published: 202510.1038/s41419-025-08393-3
Abstract
Primary and secondary bile acid (BA) levels are elevated in patients with hepatocellular carcinoma (HCC). BAs are important signaling molecules that regulate CYP8B1 expression by targeting nuclear and membrane receptors. In this study, we aimed to de…
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